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- Customer Care- 10AM to 7PM
- +91-9933332442
Patented Retinol + Growth Factor Therapy
Retibooster Treatment
Revolutionary professional retinol therapy combining 4% Retinol with 2% TGF-β (Transforming Growth Factor Beta). World's FIRST retinol-growth factor combination delivering cellular-level skin renewal through multi-directional mechanism. Reduces wrinkles, firms skin, fades pigmentation, refines pores, treats acne. Maximum efficacy, minimal irritation. Safe for all skin types. 3 sessions, 4 weeks apart. Transform your skin with cutting-edge anti-aging science.
What is Retibooster?
Retibooster is a patented professional retinol therapy representing breakthrough in anti-aging medicine—combining 4% pharmaceutical-grade Retinol with 2% TGF-β (Transforming Growth Factor Beta) for synergistic cellular renewal impossible with retinol alone. This is the FIRST formulation in the world pairing retinol with TGF-β growth factors, maximizing skin transformation efficacy while minimizing irritation potential that typically accompanies high-concentration retinol use.
Multi-directional mechanism: Retinol accelerates cellular turnover, stimulates collagen and elastin synthesis, normalizes keratinization, fades pigmentation by inhibiting melanin transfer. TGF-β amplifies these effects—signaling fibroblasts to produce more structural proteins, modulating inflammation, accelerating wound healing, enhancing epidermal barrier function. Together they create comprehensive rejuvenation pathway addressing aging at molecular level—not just surface symptoms but underlying cellular dysfunction causing visible decline. Applied topically with optional microneedling enhancement for deeper penetration when appropriate, Retibooster suitable all skin phototypes (Fitzpatrick I-VI) safely delivering professional-strength retinol benefits without typical retinization side effects (excessive peeling, redness, sensitivity) deterring many from retinol use. At Zennara, Retibooster represents next evolution retinol therapy for those seeking maximum anti-aging transformation with clinical oversight, professional protocols, proven results.
Retibooster at Zennara delivers 4% Retinol + 2% TGF-β through patented formulation achieving cellular-level renewal, wrinkle reduction, skin firming without excessive irritation. World’s first retinol-growth factor therapy.
Treatment Indications
Comprehensive anti-aging and skin renewal
- Fine lines, wrinkles, and loss of skin firmness
- Epidermal and dermal hyperpigmentation
- Enlarged pores and excess sebum production
- Compromised epidermal barrier function
- Uneven skin tone and persistent redness
- Visible signs of photoaging and chronological aging
Expected Post-Treatment Outcomes
Expected Post-Treatment Outcomes
Wrinkle Reduction
Visible reduction in fine lines, wrinkles, and acne scars
Improved Elasticity
Enhanced skin firmness and elastic fiber density
Pigmentation Fading
Reduction of epidermal and dermal hyperpigmentation including PIH
Barrier Strengthening
Reinforced epidermal barrier function and resilience
Tone Unification
Decreased redness and even skin tone across face
Pore Refinement
Reduction in sebaceous gland openings and sebum production
Essential Homecare Protocol
Maximizing and maintaining results
Meet the masters of aesthetics
DR. RICKSON PEREIRA
M.D. (Dermatology, Venereology & Leprosy),
F.C.P.S. (Dermatology & Venereology) D.D.V
(CPS, Gold Medallist), M.B.B.S.
DR. SHILPA GILL
M.D. (Dermatology, Venereology & Leprosy),
F.C.P.S. (Dermatology & Venereology) D.D.V
(CPS, Gold Medallist), M.B.B.S.
DR. JANAKI K YALAMANCHILI
M.B.B.S, M.D. Dermatology and
Fellowship in Cosmetology
Dr. SPOORTHY NAGINENI
M.B.B.S., M.D. in Dermatology,
Venereology & Leprology
Dr. MADHURYA
M.B.B.S., M.D. in Dermatology,
Venereology & Leprology
Dr. MEGHANA
M.B.B.S , M.D. Dermatology, Venereology & Leprosy (Gold medal)
DR. RICKSON PEREIRA
M.D. (Dermatology, Venereology & Leprosy), F.C.P.S. (Dermatology & Venereology) D.D.V (CPS, Gold Medallist), M.B.B.S.
DR. SHILPA GILL
M.D. (Dermatology, Venereology & Leprosy), F.C.P.S. (Dermatology & Venereology) D.D.V (CPS, Gold Medallist), M.B.B.S.
DR. JANAKI K
YALAMANCHILI
M.B.B.S, M.D. Dermatology and
Fellowship in Cosmetology
Dr. SPOORTHY NAGINENI
M.B.B.S., M.D. in Dermatology,
Venereology & Leprology
Dr. MADHURYA
M.B.B.S., M.D. in Dermatology,
Venereology & Leprology
Dr. MEGHANA
M.B.B.S , M.D. Dermatology,
Venereology & Leprosy (Gold medal)
Celebrity Love for Zennara
Celebrity Love for Zennara
Zennara was such a good, relaxing experience!
I try a lot of different facials from many places, and I can say that the ones at Zennara are my favourite and get my face seriously glowing.
Raja Kumari
Rapper and Songwriter
“Zennara was such a good, relaxing experience! I try a lot of different facials from many places, and I can say that the ones at Zennara are my favourite and get my face seriously glowing.”
Zennara was such a good, relaxing experience!
I try a lot of different facials from many places, and I can say that the ones at Zennara are my favourite and get my face seriously glowing.
Kajal Aggarwal
Indian Actress
“I love the opinions and suggestions given by the panel of doctors and the wonderful team here at Zennara”
Regina Cassandra
Indian Actress
“Right from the welcoming staff to the incredible team of doctors they have here. I truly feel well cared for and can confidently say I’m a very happy customer.”
Shriya Saran
Indian Actress
“Come to Zennara—where every visit is a step closer to inner peace, and the power of zen gives you a natural, radiant glow.”
Raja Kumari
Rapper and Songwriter
“Zennara was such a good, relaxing experience!
I try a lot of different facials from many places, and I can say that the ones at Zennara are my favourite and get my face seriously glowing.”
Kajal Aggarwal
Indian Actress
“I love the opinions and suggestions given by the panel of doctors and the wonderful team here at Zennara”
Regina Cassandra
Indian Actress
“Right from the welcoming staff to the incredible team of doctors they have here. I truly feel well cared for and can confidently say I’m a very happy customer.”
Shriya Saran
Indian Actress
“Come to Zennara—where every visit is a step closer to inner peace, and the power of zen gives you a natural, radiant glow.”
Frequently Asked Question
Retibooster fundamentally differs from consumer retinol products in concentration, formulation sophistication, and delivery method. Over-the-counter retinol typically contains 0.1-1% retinol (often lower effective concentration due to instability, poor formulation). Even “clinical strength” consumer products rarely exceed 1% and lack penetration enhancers, stabilization technology, or synergistic actives maximizing efficacy. Retibooster delivers pharmaceutical-grade 4% Retinol—4-40x higher concentration than OTC products—formulated with advanced stabilization ensuring retinol remains potent throughout treatment. But concentration alone doesn’t explain Retibooster’s superiority. The game-changer: 2% TGF-β (Transforming Growth Factor Beta) inclusion. This is FIRST and ONLY retinol formulation in world combining retinol with TGF-β growth factors. TGF-β amplifies retinol’s collagen-stimulating, cellular renewal effects while modulating inflammation, reducing irritation potential despite ultra-high retinol concentration. Clinical studies show TGF-β + retinol synergy produces superior anti-aging results versus retinol alone at any concentration. Delivery method: professional application with optional microneedling creates microchannels bypassing stratum corneum barrier, driving actives deep into viable epidermis and papillary dermis where cellular transformation occurs. OTC retinol sits on skin surface, minimal penetration. Retibooster’s 6-10 hour contact time (applied in-office, patient leaves product on overnight) ensures sustained retinol conversion to retinoic acid, prolonged TGF-β signaling impossible with nightly wash-off home products. Protocol structure: 3 sessions spaced 4 weeks apart provides cumulative collagen building, progressive transformation. Each session builds on previous, achieving results in 3 months versus 6-12+ months typical OTC retinol timelines. Professional oversight: dermatologist-supervised treatment ensures appropriate candidate selection, customized protocols, complication management if needed. Safety for all skin types including darker Fitzpatrick IV-VI often advised avoid high-strength retinoids due to PIH risk—Retibooster’s TGF-β inclusion, professional application protocols make it safe, effective even these populations. Bottom line: Retibooster isn’t just “stronger retinol”—it’s entirely different category of retinol therapy leveraging pharmaceutical concentrations, growth factor synergy, professional delivery achieving transformation impossible replicate with any home product.
Retinol and TGF-β create synergistic multi-pathway cellular renewal impossible either ingredient alone. Retinol mechanism: once absorbed into skin, retinol enzymatically converted to retinaldehyde, then retinoic acid (active form). Retinoic acid binds nuclear receptors (RAR, RXR) in keratinocytes and fibroblasts triggering gene expression changes: increased collagen I, III, elastin production; accelerated keratinocyte proliferation normalizing cellular turnover (addressing both hyperkeratinization causing clogged pores and sluggish turnover causing dullness); inhibited MMPs (matrix metalloproteinases) that degrade collagen; reduced melanin synthesis and transfer decreasing pigmentation; normalized sebaceous gland activity reducing excess oil. TGF-β mechanism: growth factor signaling molecule binding cell surface receptors activating SMAD pathway triggering: fibroblast proliferation and collagen synthesis (particularly collagen I); enhanced wound healing, tissue repair; modulated inflammation reducing cytokines causing redness, sensitivity; improved epidermal differentiation and barrier function; angiogenesis supporting tissue health. Synergy: Retinol + TGF-β attack aging from complementary angles. Retinol primarily works on keratinocytes (surface renewal, pigmentation, pore refinement) while TGF-β primarily targets fibroblasts (deep structural collagen building). Together they comprehensively rejuvenate all skin layers simultaneously. TGF-β also counterbalances retinol’s irritation potential—retinol can trigger inflammatory cascade causing redness, peeling, sensitivity deterring use. TGF-β’s anti-inflammatory, barrier-strengthening properties mitigate this allowing higher retinol concentrations tolerated without excessive side effects. Clinical validation: studies show retinol + TGF-β combination produces greater collagen synthesis, wrinkle reduction, skin thickness improvement than either ingredient alone or simple additive effect—true synergy. 4% concentration provides therapeutic threshold where transformation becomes dramatic, visible within weeks not months. 2% TGF-β sufficient amplifying retinol while maintaining safety, tolerability. This precise ratio (4:2) result extensive research optimizing efficacy-safety balance. The patented formulation ensures ingredients remain stable, active throughout treatment—major challenge combining retinol (notoriously unstable) with peptides/proteins (like TGF-β) that can degrade. Retibooster solved this through proprietary stabilization technology making this combination clinically viable first time in aesthetic medicine history.
Retibooster protocol: 3 sessions administered 4 weeks apart. This specific schedule based on skin’s natural cellular turnover cycle, collagen synthesis timeline, optimal cumulative effect without over-treating. Session 1 (Baseline): Initial treatment establishes foundation. Retinol begins accelerating cellular turnover immediately, TGF-β initiates collagen signaling. First days: possible redness, dryness as skin adjusts (normal retinoid response, typically mild with Retibooster compared to traditional high-strength retinoids). Week 1-2: surface renewal visible—improved texture, radiance, pore appearance. Deeper collagen building beginning but not yet visible. Week 3-4: progressive improvement, skin conditioning for next session. Session 2 (4 weeks later): Builds on session 1 foundation. Skin already partially “retinized” (adapted to retinol), tolerates second treatment better, achieves deeper penetration. Cumulative collagen synthesis now evident—firmness improving, fine lines softening. Sessions spaced 4 weeks because: collagen synthesis peaks 4-6 weeks post-retinoid treatment as fibroblasts respond to retinoic acid signals; cellular turnover cycle approximately 28 days—allowing complete cycle between treatments prevents over-exfoliation; skin barrier recovery requires 3-4 weeks especially if microneedling performed. Session 3 (8 weeks from baseline): Final treatment session maximizing transformation. At this point, significant collagen remodeling occurred from previous sessions. Third treatment provides final boost, “locks in” results. Why 3 sessions?: Clinical research shows 3 treatments optimal balance achieving dramatic results without over-treatment risks. Fewer than 3: results suboptimal, don’t reach transformation potential. More than 3 initial series: diminishing returns, increased irritation risk without proportional benefit. Results timeline: Immediate (same day): slight glow, hydration from Booster Serum. Weeks 1-4 post-session 1: texture improvement, radiance, pore refinement. Weeks 4-8 (after session 2): firmness increasing, wrinkles softening, pigmentation fading. Weeks 8-12 (after session 3): peak results—comprehensive transformation visible. Progressive improvement continues 2-3 months post-final session as collagen maturation completes. Maintenance: after initial 3-session series, maintenance treatments every 6-12 months sustain results long-term. Some patients choose single booster session quarterly. Homecare retinol (Retinol Intense, Retimodeling Serum) prescribed for nightly use between and after sessions maintaining cellular turnover, preventing regression. This integrated approach—professional high-intensity treatments creating transformation + consistent home maintenance preserving it—delivers lasting anti-aging results impossible either component alone.
Common concern given Retibooster’s 4% retinol concentration—highest professional-use retinol available. Truth: Retibooster designed minimizing irritation despite ultra-high concentration through TGF-β inclusion, professional protocols, patient preparation. What to expect realistically: Mild response (60-70% patients): First 24-48 hours post-treatment: slight redness (like mild sunburn), skin feeling tight, warm. Days 2-5: possible light flaking especially around mouth, nose, forehead (high cellular turnover areas). Not dramatic “sheet peeling” but fine flaking easily managed with moisturizer. Makeup concealable after 24 hours. Most continue normal activities, work without issue. Days 5-7: flaking resolves, fresh glowing skin revealed. Minimal disruption daily life. Moderate response (25-30% patients): More noticeable redness lasting 2-4 days, more visible flaking days 3-7. May prefer scheduling treatment before weekend allowing recovery time without social/professional obligations. Still manageable with proper aftercare (heavy moisturizing, gentle cleansing, strict sun avoidance). Resolves within week revealing significantly improved skin. Minimal response (5-10% patients): Almost no visible reaction. Skin tolerates treatment exceptionally well, minimal redness/flaking. These individuals often already using retinoids regularly (pre-conditioned skin) or have naturally resilient skin. Still achieve excellent results despite minimal visible “purge.” Severe response (rare, <5%): Significant redness, discomfort, extensive peeling. Usually occurs patients with extremely sensitive skin, undisclosed contraindications (recent procedures, undisclosed retinoid use), or non-compliance with aftercare (sun exposure, harsh products, picking/peeling skin). Manageable with appropriate intervention but requires medical follow-up. Why Retibooster tolerated better than expected given concentration: TGF-β anti-inflammatory properties counterbalance retinol irritation. Professional application ensures even distribution avoiding concentration hot-spots causing localized over-reaction. Pre-treatment preparation (optional 2-week Retinol Intense acclimatization) conditions skin improving tolerance. Protective barriers applied sensitive areas (around eyes, lips) preventing exposure. Post-treatment protocol (provided moisturizer, specific aftercare instructions) supports skin during renewal process. Compared to aggressive home retinoid regimens (where users apply nightly, often incorrectly, causing chronic irritation): Retibooster’s controlled professional delivery, spaced sessions, supervised protocols produce superior results with less irritation paradoxically. Analogy: professional intense workout with trainer, recovery period, proper nutrition (Retibooster) versus daily excessive exercise without guidance, rest, or support (aggressive home retinoid use). Former achieves better results, less injury despite higher intensity because it’s properly managed. Important: some visible reaction actually desirable—indicates retinol actively working, cellular turnover accelerating. Complete absence of any response might suggest under-dosing or poor penetration. Mild-moderate reaction sign treatment effective. Our practitioners assess individual tolerance, customize protocols accordingly—higher concentration/microneedling for resilient skin, gentler approach for sensitive types—ensuring optimal benefit-to-irritation ratio each patient.
Yes, Retibooster highly synergistic with other aesthetic treatments addressing aging from multiple mechanisms simultaneously. However, timing and sequencing critical maximizing benefits while avoiding complications, over-treatment. Recommended combinations: Retibooster + Peptiglow (Retix.C brasion™ protocol): Specifically designed combination. Peptiglow (acid-peptide peel) performed FIRST as preparatory step, then Retibooster applied same session. Peptiglow exfoliates removing dead cells, debris creating optimal canvas; acids increase skin permeability enhancing retinol penetration; peptides support skin during aggressive retinol treatment. This is the ultimate anti-aging combination protocol—immediate brightening from Peptiglow + progressive collagen building from Retibooster. Patients choosing Retix.C brasion™ achieve superior transformation versus either treatment alone. Retibooster + Botox/Dysport: Complementary not competitive. Botox relaxes dynamic wrinkles (forehead, crow’s feet, frown lines) while Retibooster addresses static wrinkles, texture, pigmentation, overall skin quality. Can be performed same day or spaced. No interaction between treatments. Ideal comprehensive facial rejuvenation. Retibooster + Dermal Fillers: Synergistic—fillers restore volume, Retibooster improves skin quality. Sequence matters: recommend fillers first establishing structure, wait 2 weeks, then Retibooster series improving skin covering that structure. Alternatively, Retibooster series first (skin quality foundation), then fillers 4-6 weeks after final session for volume where needed. Avoid same-day injection + retinol (infection risk through injection sites). Retibooster + Laser Treatments: Powerful combination but requires careful spacing. Aggressive ablative lasers (CO2, Erbium full resurfacing): wait 3-6 months between laser and Retibooster avoiding over-injury. Non-ablative/fractional lasers (Fraxel, Clear + Brilliant): can alternate with Retibooster spacing 4-6 weeks. Some protocols do Retibooster series, then laser 2-3 months later addressing residual concerns, vice versa. IPL (photofacials): excellent Retibooster companion for pigmentation. Can alternate treatments spacing 4 weeks. Retibooster + Microneedling/RF Microneedling: Retibooster already includes microneedling component. Additional standalone microneedling sessions can be alternated with Retibooster (e.g., microneedling month 1, Retibooster month 2, microneedling month 3, etc.) for patients wanting maximum collagen induction. RF microneedling more aggressive—space 6-8 weeks from Retibooster. Retibooster + Chemical Peels: Retibooster itself includes retinol component working similarly to peel. Additional peels generally unnecessary during active Retibooster treatment series (over-exfoliation risk). After completing series, maintenance peels (glycolic, lactic, TCA) can be performed quarterly alternating with maintenance Retibooster sessions. What to avoid: Multiple aggressive treatments too close together—over-treatment causes prolonged healing, complications, paradoxically worse results. Combining Retibooster with other strong retinoid treatments (prescription tretinoin, high-dose isotretinoin)—excessive retinoid load. Starting new aggressive treatment (deep peel, ablative laser, aggressive microneedling) within 2 weeks before/after Retibooster session. Comprehensive anti-aging plan: Many patients benefit from integrated approach using multiple modalities addressing different aging aspects. Example protocol: Months 1, 2, 3: Retibooster series (foundation). Month 5: Botox addressing dynamic wrinkles. Month 6: Filler if volume loss present. Ongoing: quarterly maintenance Retibooster or peel, annual Botox/filler touch-ups, daily homecare retinol. This comprehensive approach delivers superior, longer-lasting results versus single-modality treatment. Consultation essential determining optimal combination, sequence based on individual goals, skin condition, budget, lifestyle factors.
While Retibooster safe for most patients including all Fitzpatrick skin types, certain conditions contraindicate treatment or require special precautions. Absolute contraindications (must avoid): Pregnancy, breastfeeding—retinoids (including topical retinol) contraindicated due to potential teratogenic effects. Although topical absorption minimal compared to oral retinoids, avoiding all retinoid exposure standard medical practice during pregnancy/nursing. Wait until after breastfeeding completion before Retibooster. Active isotretinoin (Accutane) use—combining high-dose oral retinoid with professional topical retinoid excessive, dangerous retinoid load. Must discontinue isotretinoin minimum 6-12 months before Retibooster (longer period ensures skin recovered from isotretinoin’s effects on healing, barrier function). Active skin infections (bacterial, viral, fungal)—treatment would spread infection, impair healing. Wait complete resolution plus 2 weeks before proceeding. Open wounds, cuts, active inflammatory conditions—retinol on compromised skin causes severe irritation, delayed healing. Eczema, psoriasis, rosacea in active flare state—wait until controlled before retinoid treatment. Recent facial surgery or aggressive procedures (within 4-6 weeks)—skin needs full recovery before retinoid stress. Includes ablative laser resurfacing, deep chemical peels (TCA >20%, phenol), dermabrasion, facelift/blepharoplasty, etc. Retinoid allergy (rare)—documented allergic reaction to retinol, tretinoin, or other retinoids. Waxing or depilatory use on treatment areas within 1 week—retinol thins stratum corneum temporarily; waxing could remove excessive skin causing injury. Relative contraindications (caution, may proceed with modifications): Very sensitive skin, rosacea-prone (not active flare)—may require gentler protocol: no microneedling, shorter contact time, more aggressive homecare preparation, longer intervals between sessions. History of post-inflammatory hyperpigmentation—while Retibooster treats PIH, aggressive treatment can paradoxically cause it in susceptible individuals (particularly darker skin tones). Requires conservative approach, strict sun protection, possible skin-lightening pre-treatment. Recent sun exposure or upcoming sun exposure—retinol increases photosensitivity. Patients recently sunburned should postpone treatment. Those with unavoidable sun exposure upcoming (beach vacation, outdoor event) should delay treatment or ensure extreme sun protection measures. Concurrent use of other exfoliating actives—glycolic acid, salicylic acid, AHAs, BHAs, benzoyl peroxide, other prescription retinoids. May need to discontinue or reduce these 1 week before and after Retibooster avoiding over-exfoliation. History of keloid or hypertrophic scarring—microneedling component carries slight abnormal scarring risk in predisposed individuals. May omit microneedling, proceed with topical application only. Immunosuppression or impaired wound healing—diabetes, autoimmune conditions, medications affecting healing (chronic steroids, chemotherapy). Requires medical clearance, may have slower recovery, higher complication risk. Unrealistic expectations—patients expecting instant facelift results, complete pigmentation removal one treatment will be disappointed. Retibooster provides significant improvement but not miracles. Medical history review, skin assessment, detailed consultation essential determining individual suitability. Practitioners customize protocols based on skin type, concerns, tolerance, medical history ensuring safety while maximizing results. Some patients requiring gentler approach still achieve excellent outcomes with modified protocols. Open communication about medical conditions, medications, recent procedures, lifestyle factors critical safe, effective treatment.
Experience Revolutionary Retinol Therapy
Retibooster—world's first 4% Retinol + 2% TGF-β combination. Patented formulation delivering cellular-level renewal, dramatic wrinkle reduction, skin firming, pigmentation fading without excessive irritation. Safe all skin types. 3 sessions, 4 weeks apart. Professional strength, proven results, expert care. Transform your skin with cutting-edge retinol science. Book your Retibooster consultation today.
Our Clinic Locations
Jubilee Hills
