Zennara

Salmon DNA Bio-Stimulator

PDRN Treatment

Revolutionary polynucleotide therapy. Purified salmon DNA fragments activate cellular repair and regeneration. Bio-stimulation, wound healing, tissue remodeling. Exceptional for scars, sun damage, sensitive skin, anti-aging. Natural rejuvenation at cellular level.

What is PDRN Treatment?

PDRN (Polydeoxyribonucleotide) treatment uses purified polynucleotide fragments extracted from salmon DNA to activate powerful cellular repair and regeneration mechanisms in human skin. These DNA fragments are biocompatible with human tissue and work by binding to adenosine A2A receptors on skin cells, triggering cascades of regenerative responses: fibroblast stimulation producing collagen and elastin, angiogenesis creating new blood vessels improving microcirculation, anti-inflammatory effects reducing chronic skin inflammation, enhanced cellular metabolism and energy production, wound healing acceleration, antioxidant protection against free radicals.

Treatment involves multiple micro-injections delivering PDRN solution into dermis, creating temporary papules that resolve as product absorbs and spreads. Unlike fillers adding volume or Botox paralyzing muscles, PDRN triggers your cells’ own regenerative capacity—repairing damaged tissue, improving quality from within, restoring function at cellular level. Exceptional for damaged skin: acne scarring, sun damage, smoking damage, rosacea/sensitivity, post-laser recovery, thin crepey skin, compromised barriers. Also powerful anti-aging: improves elasticity, enhances radiance, refines texture through actual tissue regeneration. Protocol: 3-4 sessions spaced 2-4 weeks, results develop progressively 2-3 months, effects last 6-12 months with maintenance.

PDRN Treatment at Zennara uses pharmaceutical-grade salmon DNA polynucleotides for true cellular repair and regeneration. Also known as Rejuran therapy. Experience natural healing at DNA level.

 

Benefits of PDRN Treatment

Cellular repair and tissue regeneration

  • Cellular Regeneration
  • Wound Healing
  • Anti-Inflammatory
  • Collagen Boost
  • Scar Remodeling
  • Barrier Repair
PDRN Treatment_Zennara

Ideal Treatment Applications

 

Ideal Treatment Applications

Acne Scar Treatment

Superior for atrophic scarring. Stimulates dermal remodeling, increases collagen density, improves texture and depth. Better results than traditional approaches for scar repair.

Sun Damage Repair

Reverses UV-induced cellular damage. Repairs DNA mutations, improves photodamaged skin, restores healthy cell function. Exceptional for chronic sun exposure effects.

Smoker's Skin

Repairs smoking damage—compromised circulation, reduced oxygen, accelerated aging. Improves dull gray tone, restores vitality, enhances healing capacity significantly.

Rosacea & Sensitivity

Powerful anti-inflammatory effect reduces redness, calms reactive skin. Strengthens barrier function, improves tolerance. Ideal for chronically compromised sensitive skin.

Post-Laser Recovery

Accelerates healing after ablative laser, fractional treatments. Reduces downtime, prevents complications, enhances final results. Often used pre and post laser procedures.

Anti-Aging Rejuvenation

Comprehensive cellular regeneration. Improves elasticity, thickness, hydration, texture. Reduces fine lines through actual tissue regeneration not temporary camouflage.

Your PDRN Journey

Professional injection protocol

PDRN Transformation Results

Cellular repair and quality improvement

Acne-Clearance-Before-ZennaraAcne-Clearance-After-Zennara
Pigmentation-Correction-Before-ZennaraPigmentation-Correction-After-Zennara

Meet the masters of aesthetics

DR. RICKSON PEREIRA

M.D. (Dermatology, Venereology & Leprosy),
F.C.P.S. (Dermatology & Venereology) D.D.V
(CPS, Gold Medallist), M.B.B.S.

DR. SHILPA GILL

M.D. (Dermatology, Venereology & Leprosy),
F.C.P.S. (Dermatology & Venereology) D.D.V
(CPS, Gold Medallist), M.B.B.S.

DR. JANAKI K YALAMANCHILI

M.B.B.S, M.D. Dermatology and
Fellowship in Cosmetology

Dr. SPOORTHY NAGINENI

M.B.B.S., M.D. in Dermatology,
Venereology & Leprology

Dr. Madhurya

Dr. MADHURYA

M.B.B.S., M.D. in Dermatology,
Venereology & Leprology

Dr. MEGHANA

M.B.B.S , M.D. Dermatology, Venereology & Leprosy (Gold medal)

DR. RICKSON PEREIRA

M.D. (Dermatology, Venereology & Leprosy), F.C.P.S. (Dermatology & Venereology) D.D.V (CPS, Gold Medallist), M.B.B.S.

DR. SHILPA GILL

M.D. (Dermatology, Venereology & Leprosy), F.C.P.S. (Dermatology & Venereology) D.D.V (CPS, Gold Medallist), M.B.B.S.

DR. JANAKI K
YALAMANCHILI

M.B.B.S, M.D. Dermatology and
Fellowship in Cosmetology

DR. JANAKI K
YALAMANCHILI

M.D. (Dermatology, Venereology & Leprosy), F.C.P.S. (Dermatology & Venereology) D.D.V (CPS, Gold Medallist), M.B.B.S.

Dr. MADHURYA

M.B.B.S., M.D. in Dermatology,
Venereology & Leprology

Dr. MEGHANA

M.B.B.S , M.D. Dermatology,
Venereology & Leprosy (Gold medal)

Celebrity Love for Zennara

Celebrity Love for Zennara

Frequently Asked Question

Minimal discomfort—most patients tolerate very well: During injection: Ultra-fine needle (thinner than acupuncture). Quick pinpricks lasting 1-2 seconds each. Brief stinging sensation. Multiple injections but each very quick. Total procedure 10-15 minutes. No numbing needed typically (though ice pack optional). Pain level: Most describe 1-3 on 10-point scale. Some areas more sensitive (between brows) than others (forehead). Crow’s feet often most comfortable. Post-injection: No significant pain. Possible mild tenderness at injection sites few hours. Rare mild headache first day (treatable with over-the-counter medication). Comparison: Far less painful than dental work, blood draws, even eyebrow threading. Much more comfortable than filler injections (Botox thinner consistency, finer needle). First-timers often surprised how quick and easy. Individual variation: Pain-sensitive patients can request topical numbing (rarely needed). Anxiety increases perceived pain—most relax once they experience how tolerable it is. Overall: Brief minimal discomfort for 3-4 months of smooth, youthful results. Worthwhile trade-off for vast majority.

 

Average duration 3-4 months, individual variation: Timeline: Weeks 1-2: Results developing, peak effect achieved. Months 1-3: Beautiful maintained results. Month 3-4: Gradual return of muscle activity as Botox metabolizes. Month 4+: Most patients ready for next treatment to maintain smoothness. Factors affecting duration: Metabolism (faster metabolizers 2-3 months, slower 4-5 months). Muscle strength (stronger muscles metabolize faster). Exercise level (very active individuals may metabolize faster). First treatment (often shorter duration—2-3 months). Repeat treatments (muscles “trained” over time, duration may extend). Dose (higher appropriate doses may last longer). Area treated (forehead often lasts longer than crow’s feet). Why not permanent: Botox designed to be temporary (safety feature). Body naturally breaks down and eliminates protein. New nerve endings sprout around blocked ones restoring muscle function. Maintenance schedule: Most patients every 3-4 months. Some every 2-3 months if fast metabolizers. Others every 4-6 months if slow metabolizers. Regular treatments: Some evidence repeated Botox trains muscles requiring less frequent touch-ups long-term. Muscles atrophy slightly from disuse becoming less active even without Botox. Cost perspective: ₹400-600 per unit. Forehead+crow’s feet+frown typically 40-60 units = ₹16,000-36,000 per session. Annual cost ₹48,000-1,08,000 for 3-4 treatments. Preventive investment delaying need for more invasive procedures later.

 

Not with proper technique—natural results are achievable and expected: Why “frozen face” happens: Overdosing (too many units). Improper placement (wrong muscles targeted). Inexperienced injectors lacking facial anatomy knowledge. Patient requesting excessive correction. Treating all areas aggressively without facial balance. These are technique failures, not inherent to Botox. How to achieve natural results: Conservative dosing philosophy: Start lower, can always add at follow-up. Preserved facial expressions: You can still raise eyebrows, smile, show emotion. Just wrinkles softened, not muscles paralyzed. Strategic placement: Targeting specific wrinkle-causing muscles while preserving others. Facial harmony: Treating areas proportionally maintaining natural balance. Individual customization: Your unique muscle patterns, desired outcome considered. What natural Botox looks like: Refreshed, rested appearance. Smooth skin when face relaxed. Subtle softening when face expressive (not complete elimination of lines during movement). Still “you” just younger, less tired version. Facial expressions maintained: Can still furrow brow (just less intensely). Can raise eyebrows (just not creating deep grooves). Can smile genuinely (crow’s feet softened not eliminated). Red flags of poor results: Completely immobile forehead. Can’t raise eyebrows at all. Spock brow (outer brows lifted, inner dropped). Asymmetric facial movements. These indicate inexperienced injector—seek expert for correction. Our approach: Conservative natural philosophy. Expert placement and dosing. Beautiful subtle results. You’ll look like yourself, refreshed.

 

Virtually no downtime—true “lunchtime” procedure: Immediately after: Tiny pinpoint marks at injection sites (barely visible). Possible mild redness (resolves within 30-60 minutes). Can apply makeup immediately if desired. Resume normal activities right away. First 4 hours: Must remain upright (prevents Botox migration to unintended areas). Avoid rubbing/massaging face. No lying down, bending over, or inversions. First 24 hours: Avoid strenuous exercise (may increase bruising risk). No facials, facial massage, or other treatments. Continue normal gentle skincare routine. Possible effects: Minor swelling at injection sites (uncommon, resolves hours). Bruising (rare but possible—10-20% patients, small purple marks that fade 3-7 days, arnica helps). Mild headache (uncommon, first day only, over-the-counter pain reliever effective). Slight tenderness (normal, resolves quickly). Social downtime: Zero for most patients. Can return to work immediately. Attend social events same day. Makeup covers any tiny marks. Rare visible bruising might require concealer 2-3 days. Planning for events: Can do Botox anytime—no advance planning needed. Though optimal: 2 weeks before major event allows full results development. Activity restrictions summary: Remain upright 4 hours. No exercise 24 hours. No facial treatments 24 hours. That’s it! Comparison: Far less downtime than: Any filler (swelling 3-7 days), laser treatments (redness 5-10 days), peels (peeling 5-7 days), microneedling (redness 3-5 days). Literally the most convenient aesthetic treatment available.

 

Very safe with excellent track record, but some temporary effects possible: Common minor effects (temporary): Injection site reactions: Redness, swelling, tenderness (hours to 1-2 days). Mild headache: First day, 10-20% of patients, responds to over-the-counter pain medication. Bruising: 10-20% of patients, small purple marks fade within week. Eyelid/eyebrow asymmetry: Rare, temporary if occurs, resolves as Botox wears off 2-4 weeks. Uncommon effects (temporary, resolve): Eyelid ptosis (drooping): 1-3% of patients if Botox migrates. Temporary, improves over 2-4 weeks. Treatable with prescription eye drops. Prevented by expert placement and patient following post-care (staying upright). Eye dryness or tearing: Rare, temporary. Flu-like symptoms: Very rare, mild, resolve quickly. Rare serious events: Allergic reaction: Extremely rare (Botox used for decades, millions of treatments). Systemic effects: Not documented at cosmetic doses when properly administered. Difficulty swallowing/breathing: Theoretical risk if massive doses or improper technique—not seen with cosmetic use by qualified practitioners. Contraindications: Pregnancy/breastfeeding (precautionary, not proven harmful but avoided). Neuromuscular disorders (myasthenia gravis, ALS). Allergy to botulinum toxin or ingredients. Active infection at injection site. Certain medications (aminoglycosides, muscle relaxants). Why safe when done properly: FDA-approved since 2002. Millions of treatments annually worldwide. Decades of safety data. Purified pharmaceutical product. Tiny doses (cosmetic use far less than therapeutic). Temporary reversible effects. Local treatment only. Our safety protocols: Board-certified medical professionals only. Comprehensive medical screening. Authentic FDA-approved products. Sterile technique. Appropriate patient selection. Emergency protocols established. Overall: Among safest aesthetic procedures available with proper administration.

 

Priced per unit, total cost depends on areas treated: Per unit pricing: Range: ₹400-600 per unit typically. Factors: Practitioner expertise (experienced injectors charge premium), geographic location (metro cities higher), clinic reputation, product authenticity guarantee (genuine Botox vs. alternatives). Units needed by area: Forehead lines: 10-30 units (average 15-20). Crow’s feet: 12-24 units total both sides (average 12-16). Frown lines (11s): 20-25 units (standard dose). Bunny lines: 5-10 units. Lip flip: 4-6 units. Jawline (masseter): 40-60 units per side. Full face treatment (forehead+crow’s+frown): 40-60 units typically. Common treatment costs: Single area (forehead alone): ₹6,000-12,000. Two areas (forehead+frown): ₹12,000-20,000. Three areas (full face—forehead+crow’s+frown): ₹16,000-36,000. Specialty (masseter reduction): ₹32,000-60,000. Maintenance frequency: Every 3-4 months typically. Annual cost: Single area: ₹24,000-48,000 (4 treatments). Full face: ₹64,000-1,44,000 (4 treatments). Long-term investment: Preventive anti-aging delaying need for surgery later. More affordable than facelifts (₹3-5 lakhs). Cumulative costs over years but maintains youthful appearance. Some evidence muscles trained over time requiring less frequent treatments. Red flags for pricing: Too cheap (₹200-300/unit): Likely counterfeit product or excessive dilution. Dangerous—unknown substances, contamination risk, ineffective or harmful. Package deals pressuring upfront payment: Avoid. Pay per treatment as needed. “Botox parties” or non-medical settings: Illegal, unsafe. Our pricing: Transparent per-unit pricing. Competitive rates reflecting quality, expertise. No hidden fees or pressure. Authentic products guaranteed. Worth investment for safe, effective results from qualified professionals.

 

No “right” age—depends on individual concerns and prevention goals: Traditional timing: 30s-40s: Most common age range to begin. Wrinkles becoming visible at rest, not just with movement. Lines deepening from years of facial expressions. Excellent results at this stage. 50s+: Still beneficial but wrinkles more established (static lines present). May need combination approach (Botox + fillers + other treatments). Earlier intervention would have prevented some deepening. Preventive Botox trend: Late 20s: Increasingly popular for wrinkle prevention. Stops wrinkle formation before lines become etched in. Small doses targeting most active areas (forehead, frown lines). Controversial but growing acceptance. If starting young: Prevents deep wrinkle formation. Maintains youthful appearance longer. Requires long-term commitment (every 3-4 months indefinitely). More total cost over lifetime but arguably worth prevention. Signs you might benefit: Notice lines when face relaxed (not just when making expressions). Concerned about specific wrinkles bothering you. Family history of deep wrinkles (genetics). Expressive face, strong facial muscles. Sun damage accelerating aging. Personal choice factors: Aesthetic goals (how important is wrinkle-free appearance). Budget (can you commit to maintenance). Philosophy (comfortable with cosmetic procedures). Lifestyle (can maintain regular appointments). Not recommended if: Under 18 (not FDA-approved, unnecessary). Pregnant/breastfeeding (precautionary avoidance). Certain medical conditions (neuromuscular disorders). Unable to commit to maintenance (results temporary). Our recommendation: Start when wrinkles bother you—no judgment on age. Earlier intervention = better prevention of deep lines. But never “too late” to benefit at any age. Consultation assesses your individual situation and goals.

 

Yes—synergistic combinations provide comprehensive rejuvenation: Excellent pairings: Dermal Fillers: Botox relaxes dynamic wrinkles, fillers restore volume and fill static wrinkles. Complementary not competitive. Can do same appointment or separate. Most patients benefit from both addressing different aging mechanisms. Skin Boosters: Botox smooths wrinkles, boosters improve skin quality/hydration. Combined creates youthful appearance inside and out. Space treatments 2-4 weeks. Laser Treatments: Botox addresses wrinkles from muscle movement, lasers address texture/pigmentation/sun damage. Comprehensive skin rejuvenation. Space 2-4 weeks. Chemical Peels: Botox for wrinkles, peels for exfoliation/brightness/texture. Excellent combination. Space 2-4 weeks. Microneedling: Botox prevents new wrinkle formation, microneedling stimulates collagen for skin quality. Synergistic anti-aging. Space 2-4 weeks. Skincare: Essential! Botox addresses dynamic wrinkles, quality skincare (retinoids, vitamin C, sunscreen) maintains overall skin health. Daily regimen critical. Timing considerations: Can do Botox + fillers same day (common comprehensive approach). Space Botox and treatments causing inflammation (lasers, peels, microneedling) by 2-4 weeks. Botox first or second doesn’t matter—just space adequately. Plan comprehensive protocol: Initial consultation maps complete strategy. Address all concerns systematically over 2-3 months. Maintenance schedule coordinates all treatments efficiently. What NOT to combine: Multiple neurotoxins same session (Botox, Dysport, Xeomin—choose one). Botox immediately before/after facial surgery (wait 2 weeks minimum). Comprehensive approach benefits: Addresses all aging mechanisms: volume loss, wrinkles, texture, pigmentation. Natural holistic rejuvenation. Botox often foundation paired with other modalities customized to needs. Our recommendation: Customized multi-modal treatment plans. Botox cornerstone of most anti-aging protocols. Strategic combinations deliver most natural, complete transformation.

Critical Information

Natural results and injector expertise

Salmon DNA Science

Understanding why salmon DNA works in human skin addresses common questions about this innovative therapy.

  • Why Salmon DNA?
  • Biocompatibility: DNA structure fundamentally similar across species
  • High purity: Salmon DNA easily purified to pharmaceutical-grade
  • Rich polynucleotides: Abundant DNA fragments of optimal size
  • Sustainable source: Ethically harvested, renewable resource
  • Decades of research: Extensive safety and efficacy data
  • How It Works: Polynucleotide fragments activate adenosine A2A receptors on skin cells triggering repair cascades. Not about "salmon DNA" per se—about DNA fragments' biological signaling properties working universally across species at cellular level.

PDRN vs Other Treatments

PDRN distinct from similar-sounding treatments. Understanding differences prevents confusion and aids treatment selection.

  • Key Distinctions:
  • vs Profhilo: PDRN repairs cells via DNA, HA hydrates tissue
  • vs Exosomes: DNA fragments simpler than exosome vesicles
  • vs PRP: Purified pharmaceutical DNA vs. your blood factors
  • vs Fillers: Cellular repair mechanism not volume addition
  • Best for: Damaged skin repair, scarring, sensitivity, healing
  • Combination Strategy: Many benefit from multiple modalities—PDRN for cellular repair, Profhilo for hydration/tightening, fillers for volume. Comprehensive rejuvenation addressing all aging mechanisms synergistically.

Experience DNA-Level Skin Repair

PDRN Treatment—pharmaceutical-grade salmon polynucleotides. Cellular regeneration activation, wound healing, anti-inflammatory, collagen production. Damaged skin repair, scarring improvement, anti-aging. True tissue regeneration. Also known as Rejuran. Schedule consultation today.


Zennara Clinic Locations

Our Clinic Locations

Jubilee Hills
★★★★★ 4.9
(250+ Reviews)