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Zennara Aesthetics & Wellness
Dermal filler injection for smile lines at Zennara Clinic, Hyderabad
Salmon DNA Bio-Stimulator

PDRN Treatment in Hyderabad

Revolutionary polynucleotide therapy. Purified salmon DNA fragments activate cellular repair and regeneration. Bio-stimulation, wound healing, tissue remodeling. Exceptional for scars, sun damage, sensitive skin, anti-aging. Natural rejuvenation at cellular level.

Session
15–30 minutes
Downtime
1–2 days of small bumps
Discomfort
Minimal
Sessions
3–4, every 2–4 weeks
Results
2–3 months
Lasts
6–12 months

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  • No-obligation consultation. You decide after you see your plan.
  • A senior dermatologist sees you, not a sales counsellor.
  • Call back within minutes during clinic hours.
  • Your details stay private and are never shared.
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4.8
676 Google reviews
25,000+
Happy clients
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Industry awards
M.D.
Dermatologist-led
Since 2019
Trusted by celebrities
In short

PDRN Treatment at a glance

PDRN (polynucleotide) treatment injects purified DNA fragments that activate the skin’s own repair: more collagen, better healing and calmer skin. It suits sun damage, acne scars, sensitive skin and early ageing. The course is 3–4 sessions 2–4 weeks apart; results build over 2–3 months and last 6–12 months.

Overview

What is PDRN Treatment?

PDRN (Polydeoxyribonucleotide) treatment uses purified polynucleotide fragments extracted from salmon DNA to activate powerful cellular repair and regeneration mechanisms in human skin. These DNA fragments are biocompatible with human tissue and work by binding to adenosine A2A receptors on skin cells, triggering cascades of regenerative responses: fibroblast stimulation producing collagen and elastin, angiogenesis creating new blood vessels improving microcirculation, anti-inflammatory effects reducing chronic skin inflammation, enhanced cellular metabolism and energy production, wound healing acceleration, antioxidant protection against free radicals.

Treatment involves multiple micro-injections delivering PDRN solution into dermis, creating temporary papules that resolve as product absorbs and spreads. Unlike fillers adding volume or Anti-wrinkle paralyzing muscles, PDRN triggers your cells’ own regenerative capacity—repairing damaged tissue, improving quality from within, restoring function at cellular level. Exceptional for damaged skin: acne scarring, sun damage, smoking damage, rosacea/sensitivity, post-laser recovery, thin crepey skin, compromised barriers. Also powerful anti-aging: improves elasticity, enhances radiance, refines texture through actual tissue regeneration. Protocol: 3-4 sessions spaced 2-4 weeks, results develop progressively 2-3 months, effects last 6-12 months with maintenance.

PDRN Treatment at Zennara uses pharmaceutical-grade salmon DNA polynucleotides for true cellular repair and regeneration. Also known as Rejuran therapy. Experience natural healing at DNA level.

Why it works

Benefits of PDRN Treatment

01

Cellular repair and tissue regeneration

02

Cellular Regeneration

03

Wound Healing

04

Anti-Inflammatory

05

Collagen Boost

06

Scar Remodeling

07

Barrier Repair

08

Ideal Treatment Applications

09

Acne Scar Treatment

Superior for atrophic scarring. Stimulates dermal remodeling, increases collagen density, improves texture and depth. Better results than traditional approaches for scar repair.

10

Sun Damage Repair

Reverses UV-induced cellular damage. Repairs DNA mutations, improves photodamaged skin, restores healthy cell function. Exceptional for chronic sun exposure effects.

11

Smoker's Skin

Repairs smoking damage—compromised circulation, reduced oxygen, accelerated aging. Improves dull gray tone, restores vitality, enhances healing capacity significantly.

12

Rosacea & Sensitivity

Powerful anti-inflammatory effect reduces redness, calms reactive skin. Strengthens barrier function, improves tolerance. Ideal for chronically compromised sensitive skin.

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How it works

Revolutionary polynucleotide therapy. Purified salmon DNA fragments activate cellular repair and regeneration. Bio-stimulation, wound healing, tissue remodeling. Exceptional for scars, sun damage, sensitive skin, anti-aging. Natural rejuvenation at cellular level.

PDRN Treatment—pharmaceutical-grade salmon polynucleotides. Cellular regeneration activation, wound healing, anti-inflammatory, collagen production. Damaged skin repair, scarring improvement, anti-aging. True tissue regeneration. Also known as Rejuran. Schedule consultation today.

Is it right for you?

Who PDRN Treatment suits

Your dermatologist confirms this at the consultation, after looking at your skin and history.

A good choice if you have

  • Sun-damaged or thin, crepey skin
  • Acne scars and post-laser recovery
  • Sensitive or redness-prone skin

Not suitable, or speak to us first

  • Pregnancy or breastfeeding
  • Active infection, cold sores or acne in the area
  • Blood thinners or a bleeding disorder: speak to us first
  • Known allergy to the product or its ingredients
  • Fish or salmon allergy
Safety & recovery

PDRN Treatment: side effects and recovery

What you may notice afterwards, how we take care of it, and what each day looks like.

Possible side effect How we manage it
Small bumps or redness at injection pointsFade within hours to a day
BruisingIce and arnica; covered with makeup after 24 hours, fades within a week
Mild tenderness or swellingSettles in 1–3 days; paracetamol if needed
  1. Day 1

    Avoid makeup, workouts, saunas and alcohol; no pressing or massaging the area

  2. Day 2–3

    Small bumps or bruises fade; normal routine

  3. Week 2

    Final look settles; review appointment if advised

Your doctors

Dermatologists who perform PDRN Treatment

Choose your doctor when you book. Every treatment is doctor-led, never delegated.

Good to know

Frequently asked questions on PDRN Treatment

Does Anti-wrinkle hurt?+

Minimal discomfort—most patients tolerate very well: During injection: Ultra-fine needle (thinner than acupuncture). Quick pinpricks lasting 1-2 seconds each. Brief stinging sensation. Multiple injections but each very quick. Total procedure 10-15 minutes. No numbing needed typically (though ice pack optional). Pain level: Most describe 1-3 on 10-point scale. Some areas more sensitive (between brows) than others (forehead). Crow’s feet often most comfortable. Post-injection: No significant pain. Possible mild tenderness at injection sites few hours. Rare mild headache first day (treatable with over-the-counter medication). Comparison: Far less painful than dental work, blood draws, even eyebrow threading. Much more comfortable than filler injections (Anti-wrinkle thinner consistency, finer needle). First-timers often surprised how quick and easy. Individual variation: Pain-sensitive patients can request topical numbing (rarely needed). Anxiety increases perceived pain—most relax once they experience how tolerable it is. Overall: Brief minimal discomfort for 3-4 months of smooth, youthful results. Worthwhile trade-off for vast majority.

How long does Anti-wrinkle last?+

Average duration 3-4 months, individual variation: Timeline: Weeks 1-2: Results developing, peak effect achieved. Months 1-3: Beautiful maintained results. Month 3-4: Gradual return of muscle activity as Anti-wrinkle metabolizes. Month 4+: Most patients ready for next treatment to maintain smoothness. Factors affecting duration: Metabolism (faster metabolizers 2-3 months, slower 4-5 months). Muscle strength (stronger muscles metabolize faster). Exercise level (very active individuals may metabolize faster). First treatment (often shorter duration—2-3 months). Repeat treatments (muscles “trained” over time, duration may extend). Dose (higher appropriate doses may last longer). Area treated (forehead often lasts longer than crow’s feet). Why not permanent: Anti-wrinkle designed to be temporary (safety feature). Body naturally breaks down and eliminates protein. New nerve endings sprout around blocked ones restoring muscle function. Maintenance schedule: Most patients every 3-4 months. Some every 2-3 months if fast metabolizers. Others every 4-6 months if slow metabolizers. Regular treatments: Some evidence repeated Anti-wrinkle trains muscles requiring less frequent touch-ups long-term. Muscles atrophy slightly from disuse becoming less active even without Anti-wrinkle. Cost perspective: ₹400-600 per unit. Forehead+crow’s feet+frown typically 40-60 units = ₹16,000-36,000 per session. Annual cost ₹48,000-1,08,000 for 3-4 treatments. Preventive investment delaying need for more invasive procedures later.

Will Anti-wrinkle make me look frozen or expressionless?+

Not with proper technique—natural results are achievable and expected: Why “frozen face” happens: Overdosing (too many units). Improper placement (wrong muscles targeted). Inexperienced injectors lacking facial anatomy knowledge. Patient requesting excessive correction. Treating all areas aggressively without facial balance. These are technique failures, not inherent to Anti-wrinkle. How to achieve natural results: Conservative dosing philosophy: Start lower, can always add at follow-up. Preserved facial expressions: You can still raise eyebrows, smile, show emotion. Just wrinkles softened, not muscles paralyzed. Strategic placement: Targeting specific wrinkle-causing muscles while preserving others. Facial harmony: Treating areas proportionally maintaining natural balance. Individual customization: Your unique muscle patterns, desired outcome considered. What natural Anti-wrinkle looks like: Refreshed, rested appearance. Smooth skin when face relaxed. Subtle softening when face expressive (not complete elimination of lines during movement). Still “you” just younger, less tired version. Facial expressions maintained: Can still furrow brow (just less intensely). Can raise eyebrows (just not creating deep grooves). Can smile genuinely (crow’s feet softened not eliminated). Red flags of poor results: Completely immobile forehead. Can’t raise eyebrows at all. Spock brow (outer brows lifted, inner dropped). Asymmetric facial movements. These indicate inexperienced injector—seek expert for correction. Our approach: Conservative natural philosophy. Expert placement and dosing. Beautiful subtle results. You’ll look like yourself, refreshed.

What's the downtime after Anti-wrinkle?+

Virtually no downtime—true “lunchtime” procedure: Immediately after: Tiny pinpoint marks at injection sites (barely visible). Possible mild redness (resolves within 30-60 minutes). Can apply makeup immediately if desired. Resume normal activities right away. First 4 hours: Must remain upright (prevents Anti-wrinkle migration to unintended areas). Avoid rubbing/massaging face. No lying down, bending over, or inversions. First 24 hours: Avoid strenuous exercise (may increase bruising risk). No facials, facial massage, or other treatments. Continue normal gentle skincare routine. Possible effects: Minor swelling at injection sites (uncommon, resolves hours). Bruising (rare but possible—10-20% patients, small purple marks that fade 3-7 days, arnica helps). Mild headache (uncommon, first day only, over-the-counter pain reliever effective). Slight tenderness (normal, resolves quickly). Social downtime: Zero for most patients. Can return to work immediately. Attend social events same day. Makeup covers any tiny marks. Rare visible bruising might require concealer 2-3 days. Planning for events: Can do Anti-wrinkle anytime—no advance planning needed. Though optimal: 2 weeks before major event allows full results development. Activity restrictions summary: Remain upright 4 hours. No exercise 24 hours. No facial treatments 24 hours. That’s it! Comparison: Far less downtime than: Any filler (swelling 3-7 days), laser treatments (redness 5-10 days), peels (peeling 5-7 days), microneedling (redness 3-5 days). Literally the most convenient aesthetic treatment available.

Are there any side effects or risks?+

Very safe with excellent track record, but some temporary effects possible: Common minor effects (temporary): Injection site reactions: Redness, swelling, tenderness (hours to 1-2 days). Mild headache: First day, 10-20% of patients, responds to over-the-counter pain medication. Bruising: 10-20% of patients, small purple marks fade within week. Eyelid/eyebrow asymmetry: Rare, temporary if occurs, resolves as Anti-wrinkle wears off 2-4 weeks. Uncommon effects (temporary, resolve): Eyelid ptosis (drooping): 1-3% of patients if Anti-wrinkle migrates. Temporary, improves over 2-4 weeks. Treatable with prescription eye drops. Prevented by expert placement and patient following post-care (staying upright). Eye dryness or tearing: Rare, temporary. Flu-like symptoms: Very rare, mild, resolve quickly. Rare serious events: Allergic reaction: Extremely rare (Anti-wrinkle used for decades, millions of treatments). Systemic effects: Not documented at cosmetic doses when properly administered. Difficulty swallowing/breathing: Theoretical risk if massive doses or improper technique—not seen with cosmetic use by qualified practitioners. Contraindications: Pregnancy/breastfeeding (precautionary, not proven harmful but avoided). Neuromuscular disorders (myasthenia gravis, ALS). Allergy to botulinum toxin or ingredients. Active infection at injection site. Certain medications (aminoglycosides, muscle relaxants). Why safe when done properly: FDA-approved since 2002. Millions of treatments annually worldwide. Decades of safety data. Purified pharmaceutical product. Tiny doses (cosmetic use far less than therapeutic). Temporary reversible effects. Local treatment only. Our safety protocols: Board-certified medical professionals only. Comprehensive medical screening. Authentic FDA-approved products. Sterile technique. Appropriate patient selection. Emergency protocols established. Overall: Among safest aesthetic procedures available with proper administration.

How much does Anti-wrinkle cost?+

Priced per unit, total cost depends on areas treated: Per unit pricing: Range: ₹400-600 per unit typically. Factors: Practitioner expertise (experienced injectors charge premium), geographic location (metro cities higher), clinic reputation, product authenticity guarantee (genuine Anti-wrinkle vs. alternatives). Units needed by area: Forehead lines: 10-30 units (average 15-20). Crow’s feet: 12-24 units total both sides (average 12-16). Frown lines (11s): 20-25 units (standard dose). Bunny lines: 5-10 units. Lip flip: 4-6 units. Jawline (masseter): 40-60 units per side. Full face treatment (forehead+crow’s+frown): 40-60 units typically. Common treatment costs: Single area (forehead alone): ₹6,000-12,000. Two areas (forehead+frown): ₹12,000-20,000. Three areas (full face—forehead+crow’s+frown): ₹16,000-36,000. Specialty (masseter reduction): ₹32,000-60,000. Maintenance frequency: Every 3-4 months typically. Annual cost: Single area: ₹24,000-48,000 (4 treatments). Full face: ₹64,000-1,44,000 (4 treatments). Long-term investment: Preventive anti-aging delaying need for surgery later. More affordable than facelifts (₹3-5 lakhs). Cumulative costs over years but maintains youthful appearance. Some evidence muscles trained over time requiring less frequent treatments. Red flags for pricing: Too cheap (₹200-300/unit): Likely counterfeit product or excessive dilution. Dangerous—unknown substances, contamination risk, ineffective or harmful. Package deals pressuring upfront payment: Avoid. Pay per treatment as needed. “Anti-wrinkle parties” or non-medical settings: Illegal, unsafe. Our pricing: Transparent per-unit pricing. Competitive rates reflecting quality, expertise. No hidden fees or pressure. Authentic products guaranteed. Worth investment for safe, effective results from qualified professionals.

When should I start getting Anti-wrinkle?+

No “right” age—depends on individual concerns and prevention goals: Traditional timing: 30s-40s: Most common age range to begin. Wrinkles becoming visible at rest, not just with movement. Lines deepening from years of facial expressions. Excellent results at this stage. 50s+: Still beneficial but wrinkles more established (static lines present). May need combination approach (Anti-wrinkle + fillers + other treatments). Earlier intervention would have prevented some deepening. Preventive Anti-wrinkle trend: Late 20s: Increasingly popular for wrinkle prevention. Stops wrinkle formation before lines become etched in. Small doses targeting most active areas (forehead, frown lines). Controversial but growing acceptance. If starting young: Prevents deep wrinkle formation. Maintains youthful appearance longer. Requires long-term commitment (every 3-4 months indefinitely). More total cost over lifetime but arguably worth prevention. Signs you might benefit: Notice lines when face relaxed (not just when making expressions). Concerned about specific wrinkles bothering you. Family history of deep wrinkles (genetics). Expressive face, strong facial muscles. Sun damage accelerating aging. Personal choice factors: Aesthetic goals (how important is wrinkle-free appearance). Budget (can you commit to maintenance). Philosophy (comfortable with cosmetic procedures). Lifestyle (can maintain regular appointments). Not recommended if: Under 18 (not FDA-approved, unnecessary). Pregnant/breastfeeding (precautionary avoidance). Certain medical conditions (neuromuscular disorders). Unable to commit to maintenance (results temporary). Our recommendation: Start when wrinkles bother you—no judgment on age. Earlier intervention = better prevention of deep lines. But never “too late” to benefit at any age. Consultation assesses your individual situation and goals.

Can I combine Anti-wrinkle with other treatments?+

Yes—synergistic combinations provide comprehensive rejuvenation: Excellent pairings: Dermal Fillers: Anti-wrinkle relaxes dynamic wrinkles, fillers restore volume and fill static wrinkles. Complementary not competitive. Can do same appointment or separate. Most patients benefit from both addressing different aging mechanisms. Skin Boosters: Anti-wrinkle smooths wrinkles, boosters improve skin quality/hydration. Combined creates youthful appearance inside and out. Space treatments 2-4 weeks. Laser Treatments: Anti-wrinkle addresses wrinkles from muscle movement, lasers address texture/pigmentation/sun damage. Comprehensive skin rejuvenation. Space 2-4 weeks. Chemical Peels: Anti-wrinkle for wrinkles, peels for exfoliation/brightness/texture. Excellent combination. Space 2-4 weeks. Microneedling: Anti-wrinkle prevents new wrinkle formation, microneedling stimulates collagen for skin quality. Synergistic anti-aging. Space 2-4 weeks. Skincare: Essential! Anti-wrinkle addresses dynamic wrinkles, quality skincare (retinoids, vitamin C, sunscreen) maintains overall skin health. Daily regimen critical. Timing considerations: Can do Anti-wrinkle + fillers same day (common comprehensive approach). Space Anti-wrinkle and treatments causing inflammation (lasers, peels, microneedling) by 2-4 weeks. Anti-wrinkle first or second doesn’t matter—just space adequately. Plan comprehensive protocol: Initial consultation maps complete strategy. Address all concerns systematically over 2-3 months. Maintenance schedule coordinates all treatments efficiently. What NOT to combine: Multiple neurotoxins same session (Anti-wrinkle, Dysport, Xeomin—choose one). Anti-wrinkle immediately before/after facial surgery (wait 2 weeks minimum). Comprehensive approach benefits: Addresses all aging mechanisms: volume loss, wrinkles, texture, pigmentation. Natural holistic rejuvenation. Anti-wrinkle often foundation paired with other modalities customized to needs. Our recommendation: Customized multi-modal treatment plans. Anti-wrinkle cornerstone of most anti-aging protocols. Strategic combinations deliver most natural, complete transformation.

From our blog

Read more about PDRN Treatment

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Credentials

Why clients trust Zennara

M.D. Dermatologists

Every treatment led by qualified, registered doctors

FDA-approved technology

Lasers and devices from globally certified makers

Sterile protocols

Single-use consumables and medical-grade hygiene

Written treatment plan

Sessions, timeline and price agreed before you start

Consent-first

No photos or records shared without written consent

Award-winning clinic

Recognised at the Forttuna Global Excellence Awards

Doctor’s tips

Skin & hair advice from our dermatologists

Short, honest tips every week. Follow along on Instagram.

Why your dermatologist’s advice is personal to you
Viral skincare hacks: what actually changes your skin
No magic product: the habits that work (and daily SPF)
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Find us

PDRN Treatment near you

Three private clinics across Hyderabad. Choose one to see the map, today’s hours and directions.

Private consultation

Ready to start PDRN Treatment?

Tell us when suits you. A senior dermatologist will see you in a private room, explain your plan and share exact pricing. No pressure, no waiting room.

  • No-obligation consultation. You decide after you see your plan.
  • A senior dermatologist sees you, not a sales counsellor.
  • Call back within minutes during clinic hours.
  • Your details stay private and are never shared.
+91 99333 32442

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